Holmes G P, Kaplan J E, Gantz N M, Komaroff A L, Schonberger L B, Straus S E, Jones J F, Dubois R E, Cunningham-Rundles C, Pahwa S
Division of Viral Diseases, Centers for Disease Control, Atlanta, Georgia.
Ann Intern Med. 1988 Mar;108(3):387-9. doi: 10.7326/0003-4819-108-3-387.
The chronic Epstein-Barr virus syndrome is a poorly defined symptom complex characterized primarily by chronic or recurrent debilitating fatigue and various combinations of other symptoms, including sore throat, lymph node pain and tenderness, headache, myalgia, and arthralgias. Although the syndrome has received recent attention, and has been diagnosed in many patients, the chronic Epstein-Barr virus syndrome has not been defined consistently. Despite the name of the syndrome, both the diagnostic value of Epstein-Barr virus serologic tests and the proposed causal relationship between Epstein-Barr virus infection and patients who have been diagnosed with the chronic Epstein-Barr virus syndrome remain doubtful. We propose a new name for the chronic Epstein-Barr virus syndrome--the chronic fatigue syndrome--that more accurately describes this symptom complex as a syndrome of unknown cause characterized primarily by chronic fatigue. We also present a working definition for the chronic fatigue syndrome designed to improve the comparability and reproducibility of clinical research and epidemiologic studies, and to provide a rational basis for evaluating patients who have chronic fatigue of undetermined cause.
慢性爱泼斯坦-巴尔病毒综合征是一种定义不明确的症状复合体，主要特征为慢性或复发性使人衰弱的疲劳以及其他各种症状的不同组合，包括咽喉疼痛、淋巴结疼痛和压痛、头痛、肌痛和关节痛。尽管该综合征最近受到了关注，且已在许多患者中得到诊断，但慢性爱泼斯坦-巴尔病毒综合征的定义并不一致。尽管有该综合征的名称，但爱泼斯坦-巴尔病毒血清学检测的诊断价值以及爱泼斯坦-巴尔病毒感染与被诊断为慢性爱泼斯坦-巴尔病毒综合征患者之间拟议的因果关系仍存疑问。我们为爱泼斯坦-巴尔病毒综合征提出一个新名称——慢性疲劳综合征，它能更准确地将这种症状复合体描述为一种病因不明、主要以慢性疲劳为特征的综合征。我们还给出了慢性疲劳综合征的实用定义，旨在提高临床研究和流行病学研究的可比性及可重复性，并为评估病因不明的慢性疲劳患者提供合理依据。
