Chao C C, DeLaHunt M, Hu S, Close K, Peterson P K
Neuroimmunobiology and Host Defense Laboratory, Minneapolis Medical Research Foundation, Minnesota 55404.
Clin Immunol Immunopathol. 1992 Aug;64(2):161-5. doi: 10.1016/0090-1229(92)90194-s.
Chronic fatigue syndrome (CFS) is an idiopathic disorder in which the chief symptoms is profound fatigue. To explore the relationship between immune stimulation and fatigue, we developed a murine model for quantifying fatigue: reduction in voluntary running and delayed initiation of grooming after swimming. Inoculation of female BALB/c mice with Corynebacterium parvum antigen or the relatively avirulent Me49 strain of Toxoplasma gondii induced fatigue: baseline running reduced to less than 50 and 30% for 8 and 14 days, respectively, and delayed initiation of grooming after swimming in both immunologically stimulated groups. A threefold evaluation of serum transforming growth factor-beta levels, a cytokine increased in CFS patients, was found in fatigued C. parvum- and T. gondii-inoculated mice. This murine model appears promising for investigation of the pathogenesis of immunologically mediated fatigue.
慢性疲劳综合征（CFS）是一种特发性疾病，其主要症状是严重疲劳。为了探究免疫刺激与疲劳之间的关系，我们建立了一种用于量化疲劳的小鼠模型：游泳后自愿跑动减少以及梳理毛发起始时间延迟。用微小棒状杆菌抗原或相对无毒的刚地弓形虫Me49株接种雌性BALB/c小鼠可诱发疲劳：在两个免疫刺激组中，基线跑动分别在8天和14天降至低于50%和30%，且游泳后梳理毛发的起始时间延迟。在接种微小棒状杆菌和弓形虫而疲劳的小鼠中，发现血清转化生长因子-β水平有三倍的升高，该细胞因子在CFS患者中会升高。这种小鼠模型对于研究免疫介导性疲劳的发病机制似乎很有前景。
