克罗恩病中针对副结核分枝杆菌种特异性重组多肽的抗体的出现。
Occurrence, in Crohn's disease, of antibodies directed against a species-specific recombinant polypeptide of Mycobacterium paratuberculosis.
作者信息
Vannuffel P, Dieterich C, Naerhuyzen B, Gilot P, Coene M, Fiasse R, Cocito C
机构信息
Microbiology and Genetics Unit, University of Louvain, Brussels, Belgium.
出版信息
Clin Diagn Lab Immunol. 1994 Mar;1(2):241-3. doi: 10.1128/cdli.1.2.241-243.1994.
Abstract
Sera from patients with Crohn's disease and control were analyzed by an enzyme-linked immunosorbent assay based on the Mycobacterium paratuberculosis-specific recombinant polypeptide a362. Anti-a362 immunoglobulin G (IgG) (P < 0.05) and IgA (P < 0.001) titers were higher in patients with Crohn's disease than in controls. A monomodal Gaussian distribution of anti-a362 IgA levels were found for controls, and a bimodal distribution was found for patients with Crohn's disease. An M. paratuberculosis etiology is suggested for the 36% of patients with Crohn's disease who had an anti-a362 IgA level higher than that of controls.
摘要
采用基于副结核分枝杆菌特异性重组多肽a362的酶联免疫吸附测定法，对克罗恩病患者和对照者的血清进行分析。克罗恩病患者的抗a362免疫球蛋白G（IgG）（P<0.05）和IgA（P<0.001）滴度高于对照者。对照者的抗a362 IgA水平呈单峰高斯分布，而克罗恩病患者呈双峰分布。对于36%抗a362 IgA水平高于对照者的克罗恩病患者，提示其病因与副结核分枝杆菌有关。
相似文献
1
Occurrence, in Crohn's disease, of antibodies directed against a species-specific recombinant polypeptide of Mycobacterium paratuberculosis.克罗恩病中针对副结核分枝杆菌种特异性重组多肽的抗体的出现。
Clin Diagn Lab Immunol. 1994 Mar;1(2):241-3. doi: 10.1128/cdli.1.2.241-243.1994.
2
Antibodies to Mycobacterium paratuberculosis and nine species of environmental mycobacteria in Crohn's disease and control subjects.克罗恩病患者及对照人群中抗副结核分枝杆菌和九种环境分枝杆菌的抗体
Gut. 1993 Mar;34(3):371-4. doi: 10.1136/gut.34.3.371.
3
Serum antibodies to Mycobacterium paratuberculosis in patients with Crohn's disease.克罗恩病患者血清中副结核分枝杆菌抗体
Dig Dis Sci. 1999 Jun;44(6):1202-7. doi: 10.1023/a:1026692627460.
4
Mycobacterium avium subsp. paratuberculosis in Crohn's disease is serologically positive.克罗恩病中的副结核分枝杆菌鸟亚种血清学呈阳性。
Clin Diagn Lab Immunol. 1999 Mar;6(2):282. doi: 10.1128/CDLI.6.2.282-282.1999.
5
Characterization of Mycobacterium paratuberculosis p36 antigen and its seroreactivities in Crohn's disease.副结核分枝杆菌p36抗原的特性及其在克罗恩病中的血清反应性
Curr Microbiol. 1999 Aug;39(2):115-9. doi: 10.1007/s002849900430.
6
Antibodies against Mycobacterium paratuberculosis in Crohn's disease.克罗恩病中抗副结核分枝杆菌抗体
QJM. 1996 Mar;89(3):217-21. doi: 10.1093/qjmed/89.3.217.
7
8
Development of species-specific enzyme-linked immunosorbent assay for diagnosis of Johne's disease in cattle.用于诊断牛副结核病的种特异性酶联免疫吸附测定法的开发。
J Clin Microbiol. 1994 May;32(5):1211-6. doi: 10.1128/jcm.32.5.1211-1216.1994.
9
Effect of intestinal resection on serum antibodies to the mycobacterial 45/48 kilodalton doublet antigen in Crohn's disease.肠道切除对克罗恩病患者血清中针对分枝杆菌45/48千道尔顿双联体抗原抗体的影响。
Gut. 1995 Sep;37(3):361-6. doi: 10.1136/gut.37.3.361.
10
Specific IgG response against Mycobacterium avium paratuberculosis in children and adults with Crohn's disease.儿童和成人克罗恩病患者中针对分枝杆菌副结核的特异性 IgG 反应。
PLoS One. 2013 May 2;8(5):e62780. doi: 10.1371/journal.pone.0062780. Print 2013.
引用本文的文献
1
The zoonotic potential of Mycobacterium avium ssp. paratuberculosis: a systematic review and meta-analyses of the evidence.鸟分枝杆菌副结核亚种的人畜共患病潜力：证据的系统评价和荟萃分析
Epidemiol Infect. 2015 Nov;143(15):3135-57. doi: 10.1017/S095026881500076X. Epub 2015 May 20.
2
The zoonotic potential of Mycobacterium avium spp. paratuberculosis: a systematic review.鸟分枝杆菌副结核亚种的人畜共患病潜力：一项系统综述
Can J Public Health. 2008 Mar-Apr;99(2):145-55. doi: 10.1007/BF03405464.
3
Current understanding of fungal microflora in inflammatory bowel disease pathogenesis.目前对炎症性肠病发病机制中真菌微生物群的认识。
Inflamm Bowel Dis. 2008 Aug;14(8):1147-53. doi: 10.1002/ibd.20402.
4
Familial expression of anti-Saccharomyces cerevisiae mannan antibodies in affected and unaffected relatives of patients with Crohn's disease.克罗恩病患者的患病及未患病亲属中抗酿酒酵母甘露聚糖抗体的家族性表达
Gut. 2000 Jan;46(1):58-63. doi: 10.1136/gut.46.1.58.
5
Identification of a novel mycobacterial histone H1 homologue (HupB) as an antigenic target of pANCA monoclonal antibody and serum immunoglobulin A from patients with Crohn's disease.鉴定一种新型分枝杆菌组蛋白H1同源物（HupB）作为克罗恩病患者中pANCA单克隆抗体和血清免疫球蛋白A的抗原靶点。
Infect Immun. 1999 Dec;67(12):6510-7. doi: 10.1128/IAI.67.12.6510-6517.1999.
6
Detection of Mycobacterium avium subsp. paratuberculosis in infected tissues by new species-specific immunohistological procedures.通过新的种特异性免疫组织学方法检测感染组织中的副结核分枝杆菌。
Clin Diagn Lab Immunol. 1998 Jul;5(4):446-51. doi: 10.1128/CDLI.5.4.446-451.1998.
7
Paratuberculosis.副结核病
Clin Microbiol Rev. 1994 Jul;7(3):328-45. doi: 10.1128/CMR.7.3.328.
本文引用的文献
1
Identification of spheroplast-like agents isolated from tissues of patients with Crohn's disease and control tissues by polymerase chain reaction.通过聚合酶链反应从克罗恩病患者组织和对照组织中分离出类原生质球样病原体的鉴定。
J Clin Microbiol. 1993 May;31(5):1241-5. doi: 10.1128/jcm.31.5.1241-1245.1993.
2
Antibodies to Mycobacterium paratuberculosis and nine species of environmental mycobacteria in Crohn's disease and control subjects.克罗恩病患者及对照人群中抗副结核分枝杆菌和九种环境分枝杆菌的抗体
Gut. 1993 Mar;34(3):371-4. doi: 10.1136/gut.34.3.371.
3
Isolation and sequencing of the gene coding for an antigenic 34-kilodalton protein of Mycobacterium paratuberculosis.副结核分枝杆菌34千道尔顿抗原蛋白编码基因的分离与测序
J Bacteriol. 1993 Aug;175(15):4930-5. doi: 10.1128/jb.175.15.4930-4935.1993.
4
Cloning and expression of portions of the 34-kilodalton-protein gene of Mycobacterium paratuberculosis: its application to serological analysis of Johne's disease.
J Clin Microbiol. 1993 Apr;31(4):947-54. doi: 10.1128/jcm.31.4.947-954.1993.
5
Characteristics of an unclassified Mycobacterium species isolated from patients with Crohn's disease.从克罗恩病患者中分离出的一种未分类分枝杆菌的特征。
J Clin Microbiol. 1984 Nov;20(5):966-71. doi: 10.1128/jcm.20.5.966-971.1984.
6
Ruminant paratuberculosis (Johne's disease): the current status and future prospects.反刍动物副结核病（约内氏病）：现状与未来展望
Cornell Vet. 1984 Jul;74(3):218-62.
7
Mycobacterial aetiology of Crohn's disease: serologic study using common mycobacterial antigens and a species-specific glycolipid antigen from Mycobacterium paratuberculosis.克罗恩病的分枝杆菌病因：使用常见分枝杆菌抗原和来自副结核分枝杆菌的种特异性糖脂抗原的血清学研究
Gut. 1986 Nov;27(11):1353-6. doi: 10.1136/gut.27.11.1353.
8
No evidence for antibodies to mycobacterial A60 antigen in Crohn's disease sera by enzyme-linked immunoabsorbent assay (ELISA).通过酶联免疫吸附测定（ELISA）未发现克罗恩病血清中存在抗分枝杆菌A60抗原的抗体。
J Med Microbiol. 1988 Apr;25(4):295-8. doi: 10.1099/00222615-25-4-295.
9
Crohn's disease and the mycobacterioses: a review and comparison of two disease entities.克罗恩病与分枝杆菌病：两种疾病实体的综述与比较
Clin Microbiol Rev. 1989 Jan;2(1):90-117. doi: 10.1128/CMR.2.1.90.
10
Analysis of human antibody epitopes on the 65-kilodalton protein of Mycobacterium leprae by using synthetic peptides.利用合成肽分析麻风分枝杆菌65千道尔顿蛋白上的人抗体表位
Infect Immun. 1989 Dec;57(12):3689-94. doi: 10.1128/iai.57.12.3689-3694.1989.
Zotero 插件