果蝇对果蝇C病毒易感性的宿主遗传控制
Drosophila-host genetic control of susceptibility to Drosophila C virus.
作者信息
Thomas-Orillard M, Jeune B, Cusset G
机构信息
Université Pierre-et-Marie Curie, Paris, France.
出版信息
Genetics. 1995 Aug;140(4):1289-95. doi: 10.1093/genetics/140.4.1289.
Interactions between Drosophila C virus (DCV) and its natural host, Drosophila melanogaster, were investigated using 15 geographical population samples infected by intraabdominal inoculation. These strains derived from natural populations of D. melanogaster differed in susceptibility to the DCVc. One strain was "partially tolerant". Isofemale lines obtained from one susceptible and one partially tolerant strain were studied. The partially tolerant phenotype was dominant, and there was no difference between F1 progeny of direct and reciprocal crosses. Analysis of F2 progeny showed that neither sex-linked genes nor maternal effects are involved in susceptibility to DCVc. The partially tolerant strain phenotype was dominant and segregated with chromosome III. Two nonexclusive hypotheses are proposed to explain chromosome III gene action.
利用通过腹腔接种感染的15个地理种群样本，对果蝇C病毒（DCV）与其天然宿主黑腹果蝇之间的相互作用进行了研究。这些源自黑腹果蝇自然种群的菌株对DCVc的易感性有所不同。其中一个菌株是“部分耐受的”。对从一个易感菌株和一个部分耐受菌株获得的同雌系进行了研究。部分耐受表型是显性的，正反交的F1后代之间没有差异。对F2后代的分析表明，DCVc易感性既不涉及性连锁基因，也不涉及母体效应。部分耐受菌株的表型是显性的，并与三号染色体一起分离。提出了两个并非相互排斥的假说来解释三号染色体基因的作用。
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