Schröder J, Stüber F, Gallati H, Schade F U, Kremer B
Klinik für Allgemeine Chirurgie und Thoraxchirurgie, Klinikum der Christian-Albrechts-Universität zu Kiel, Germany.
Infection. 1995 May-Jun;23(3):143-8. doi: 10.1007/BF01793854.
The serum levels of soluble TNF receptors I (sTNFR I) and sTNFR II were measured frequently in 14 patients with sepsis to evaluate the pattern of these TNF antagonists in relation to TNF alpha, Soluble TNFR I and II could be detected in all samples with significantly higher levels (p < 0.001) compared to healthy controls. The concentration of sTNFR I as well as sTNFR II was significantly higher in nonsurvivors compared to survivors during the first 36 h of sepsis (p < 0.001). Levels remained elevated throughout the evaluation with maximal values in patients who died. A positive correlation exists between both receptors and between soluble receptors and simultaneously obtained sepsis score (p < 0.01) while TNF immunoreactivity detected in 80% of all samples did not correlate to soluble receptor levels or sepsis score. Soluble receptors were constantly found in the circulation representing the inflammatory state throughout the evaluation even when TNF activity was undetectable.
对14例脓毒症患者频繁检测血清可溶性肿瘤坏死因子受体I（sTNFR I）和sTNFR II水平，以评估这些肿瘤坏死因子拮抗剂与肿瘤坏死因子α相关的模式。与健康对照相比，在所有样本中均可检测到可溶性TNFR I和II，其水平显著更高（p < 0.001）。在脓毒症的最初36小时内，非存活者的sTNFR I以及sTNFR II浓度与存活者相比显著更高（p < 0.001）。在整个评估过程中，水平持续升高，死亡患者达到最大值。两种受体之间以及可溶性受体与同时获得的脓毒症评分之间存在正相关（p < 0.01），而在所有样本的80%中检测到的肿瘤坏死因子免疫反应性与可溶性受体水平或脓毒症评分无关。即使在检测不到肿瘤坏死因子活性时，在整个评估过程中循环中持续存在可溶性受体，代表炎症状态。
