Characteristics of cloned cerebrovascular endothelial cells following infection with Theiler's virus. I. Acute infection.

作者信息

Welsh C J, Sapatino B V, Rosenbaum B A, Smith R

机构信息

Department of Veterinary Anatomy and Public Health, College of Veterinary Medicine, Texas A&M University, College Station 77843-4458, USA.

出版信息

J Neuroimmunol. 1995 Nov;62(2):119-25. doi: 10.1016/0165-5728(95)00093-2.

DOI:10.1016/0165-5728(95)00093-2

PMID:7499499

Abstract

The present study describes the replication of Theiler's virus in cloned cerebrovascular endothelial cells (CVE) isolated from strains of mice that are either susceptible or resistant to Theiler's virus-induced demyelination (TVID). CVE isolated from all strains of mice were equally permissive to Theiler's virus infection. Interferon-gamma and tumor necrosis factor-alpha were found to inhibit the replication of Theiler's virus in CVE. A correlation between susceptibility to demyelination and the ability of Theiler's virus to induce MHC Class I on CVE was demonstrated.

摘要