Welsh C J, Sapatino B V, Rosenbaum B A, Smith R
Department of Veterinary Anatomy and Public Health, College of Veterinary Medicine, Texas A&M University, College Station 77843-4458, USA.
J Neuroimmunol. 1995 Nov;62(2):119-25. doi: 10.1016/0165-5728(95)00093-2.
The present study describes the replication of Theiler's virus in cloned cerebrovascular endothelial cells (CVE) isolated from strains of mice that are either susceptible or resistant to Theiler's virus-induced demyelination (TVID). CVE isolated from all strains of mice were equally permissive to Theiler's virus infection. Interferon-gamma and tumor necrosis factor-alpha were found to inhibit the replication of Theiler's virus in CVE. A correlation between susceptibility to demyelination and the ability of Theiler's virus to induce MHC Class I on CVE was demonstrated.
本研究描述了泰勒氏病毒在从对泰勒氏病毒诱导的脱髓鞘（TVID）敏感或抗性的小鼠品系中分离出的克隆脑血管内皮细胞（CVE）中的复制情况。从所有小鼠品系中分离出的CVE对泰勒氏病毒感染的易感性相同。发现γ干扰素和肿瘤坏死因子-α可抑制泰勒氏病毒在CVE中的复制。研究证明了对脱髓鞘的易感性与泰勒氏病毒在CVE上诱导MHC I类分子的能力之间存在相关性。
