感染泰勒氏病毒后克隆脑血管内皮细胞的特征。I. 急性感染。

Characteristics of cloned cerebrovascular endothelial cells following infection with Theiler's virus. I. Acute infection.

作者信息

Welsh C J, Sapatino B V, Rosenbaum B A, Smith R

机构信息

Department of Veterinary Anatomy and Public Health, College of Veterinary Medicine, Texas A&M University, College Station 77843-4458, USA.

出版信息

J Neuroimmunol. 1995 Nov;62(2):119-25. doi: 10.1016/0165-5728(95)00093-2.

DOI:10.1016/0165-5728(95)00093-2

PMID:7499499

Abstract

The present study describes the replication of Theiler's virus in cloned cerebrovascular endothelial cells (CVE) isolated from strains of mice that are either susceptible or resistant to Theiler's virus-induced demyelination (TVID). CVE isolated from all strains of mice were equally permissive to Theiler's virus infection. Interferon-gamma and tumor necrosis factor-alpha were found to inhibit the replication of Theiler's virus in CVE. A correlation between susceptibility to demyelination and the ability of Theiler's virus to induce MHC Class I on CVE was demonstrated.

摘要

本研究描述了泰勒氏病毒在从对泰勒氏病毒诱导的脱髓鞘（TVID）敏感或抗性的小鼠品系中分离出的克隆脑血管内皮细胞（CVE）中的复制情况。从所有小鼠品系中分离出的CVE对泰勒氏病毒感染的易感性相同。发现γ干扰素和肿瘤坏死因子-α可抑制泰勒氏病毒在CVE中的复制。研究证明了对脱髓鞘的易感性与泰勒氏病毒在CVE上诱导MHC I类分子的能力之间存在相关性。