Welsh J, Sapatino B, Rosenbaum B, Smith R, Linthicum S
Department of Veterinary Anatomy and Public Health, College of Veterinary Medicine, Texas A & M University, College Station 77843-4458.
J Neuroimmunol. 1993 Oct;48(1):91-7. doi: 10.1016/0165-5728(93)90062-4.
The induction of major histocompatibility complex (MHC) Class II expression was studied on cerebrovascular endothelial cells (CVE) obtained from strains of mice that are resistant (BALB/c) and susceptible (SJL and CBA) to Theiler's virus-induced demyelination (TVID). Following 24 h treatment with interferon (IFN)-gamma, MHC Class II was induced on CVE derived from susceptible but not resistant strains of mice. However, IFN-gamma induced the expression of MHC Class II on late passages of BALB/c CVE. These results demonstrate a correlation between susceptibility to demyelination and the ability of IFN-gamma to induce the expression of MHC Class II on CVE. In susceptible strains of mice, the presence of activated, IFN-gamma-secreting T cells, in the vicinity of CVE would increase the antigen-presenting capabilities of CVE and result in increased T cell traffic into the central nervous system.
研究了主要组织相容性复合体（MHC）II类表达在从对泰勒氏病毒诱导的脱髓鞘（TVID）有抗性（BALB/c）和易感性（SJL和CBA）的小鼠品系获得的脑血管内皮细胞（CVE）上的诱导情况。在用干扰素（IFN）-γ处理24小时后，MHC II类在源自易感但非抗性小鼠品系的CVE上被诱导。然而，IFN-γ在BALB/c CVE的后期传代中诱导了MHC II类的表达。这些结果表明脱髓鞘易感性与IFN-γ诱导CVE上MHC II类表达的能力之间存在相关性。在易感小鼠品系中，CVE附近存在活化的、分泌IFN-γ的T细胞会增加CVE的抗原呈递能力，并导致进入中枢神经系统的T细胞流量增加。
