Lefvert A K
Clin Exp Immunol. 1978 Oct;34(1):111-7.
A specific immunoglobulin, the receptor antibody, can be found in most patients with myasthenia gravis. In order to study the kinetic properties of this antibody, serial determinations of receptor antibody, total IgG and IgG 3 were made during drainage of thoracic duct lymph in three patients. The values obtained were used in a mathematical model to calculate some kinetic parameters. Values for T 1/2 and fractional rates of synthesis and catabolism obtained for total IgG and IgG 3 by this method were shown to agree with those found with other techniques. Most of the receptor antibody activity was found in the IgG 3 fraction but the receptor antibody had a shorter T 1/2 and higher fractional rates of synthesis and catabolism than IgG 3. These kinetic characteristics are consistent with rapid variations in plasma concentration of the receptor antibody. The cause of this rapid turnover could be strong antigenic stimuli and rapid elimination by the antigen, the cholinergic receptor protein.
一种特异性免疫球蛋白，即受体抗体，可在大多数重症肌无力患者体内发现。为研究该抗体的动力学特性，对3例患者胸导管淋巴引流过程中的受体抗体、总IgG和IgG 3进行了系列测定。所得数值用于数学模型以计算一些动力学参数。通过该方法获得的总IgG和IgG 3的T 1/2以及合成和分解代谢分数率的值与其他技术所发现的值相符。大部分受体抗体活性存在于IgG 3组分中，但受体抗体的T 1/2较短，合成和分解代谢分数率高于IgG 3。这些动力学特征与受体抗体血浆浓度的快速变化一致。这种快速周转的原因可能是强烈的抗原刺激以及抗原（胆碱能受体蛋白）的快速清除。
