Prokof'ev V N, Mogil'nitskaia L V, Morgulis G L, Sherstneva I Ia
Patol Fiziol Eksp Ter. 1995 Jul-Sep(3):40-3.
Monitoring was made to examine the lungs. With this mode of hyperbaric oxygenation (0.3 MPa for 5 hours), rats developed mild oxygen intoxication which alleviated on day 3 and ceased on day 7 after its exposure. At the same time there were profound changes in the surfactant levels of protein, phospholipids, and cholesterol, which became normal on day 7 of postexposure. Chemiluminescence analysis and measurements of lipid peroxidation (PLO) products indicated that PLO rates in the surfactant decreased during hyperbaric oxygenation and remained at low levels within 24 hours of postexposure, whose cause might be activated by the antioxidative systems, as considered by the authors. However, on day 3 PLO enhances and on day 7 a new level of free-radical processes established, which was characterized by higher concentrations of free radicals and enhanced the activity of the antiradical systems.
对大鼠肺部进行监测。在这种高压氧疗模式下（0.3兆帕，持续5小时），大鼠出现轻度氧中毒，在暴露后第3天症状缓解，并在第7天停止。与此同时，表面活性剂中蛋白质、磷脂和胆固醇的水平发生了显著变化，在暴露后第7天恢复正常。化学发光分析和脂质过氧化（PLO）产物的测量表明，在高压氧疗期间表面活性剂中的PLO速率降低，并在暴露后24小时内保持在低水平，作者认为其原因可能是抗氧化系统被激活。然而，在第3天PLO增强，在第7天建立了新的自由基过程水平，其特征是自由基浓度更高，抗自由基系统的活性增强。
