急性酸碱改变对犬谷氨酰胺代谢及肾脏氨生成的影响。

Effects of acute acid--base alterations on glutamine metabolism and renal ammoniagenesis in the dog.

Fine A, Bennett F I, Alleyne G A

Clin Sci Mol Med. 1978 May;54(5):503-8. doi: 10.1042/cs0540503.

Abstract

The effects of acute acid-base alterations on renal ammonia production and glutamine metabolism were studied in anaesthetized dogs. 2. Plasma glutamine rose with acidosis and also when both PCO2 and plasma HCO-3 were raised isohydrically. 3. Blood urea fell when acidosis was induced with hydrochloric acid. 4. The renal production of ammonia per ml of renal blood flow was increased in acidosis, but this was independent of the amount of glutamine delivered to the kidney. 5. The results indicate that acute acidosis affects production of urea and glutamine and increases the capacity of the renal cells to extract glutamine from blood.

摘要

在麻醉犬身上研究了急性酸碱改变对肾氨生成和谷氨酰胺代谢的影响。2. 酸中毒时血浆谷氨酰胺升高，当PCO2和血浆HCO-3等渗升高时也会升高。3. 用盐酸诱发酸中毒时血尿素下降。4. 酸中毒时每毫升肾血流量的肾氨生成增加，但这与输送到肾脏的谷氨酰胺量无关。5. 结果表明，急性酸中毒影响尿素和谷氨酰胺的生成，并增加肾细胞从血液中提取谷氨酰胺的能力。