Cohen P R, Kazi S, Grossman M E
Department of Dermatology, University of Texas-Houston Medical School 77030, USA.
South Med J. 1995 Dec;88(12):1231-5.
Two immunocompromised patients with herpetic geometric glossitis, a clinically distinctive form of lingual herpes simplex virus (HSV) type 1 infection, are described. The significant features of herpetic geometric glossitis are summarized, the clinical differential diagnosis of this form of HSV infection is reviewed, and the possible pathogenesis of these lingual lesions is discussed. Both of our patients, as well as all previously described patients with this condition, had extremely painful cross-hatched, branched, and/or linear fissures on the dorsal aspect of the tongue. Symptoms promptly resolved within 1 to 2 days, and the fissures subsequently healed within 3 to 12 days after systemic acyclovir therapy was initiated. In contrast to tongue lesions of herpetic geometric glossitis, similar-appearing lingual lesions of other conditions are usually asymptomatic. The similar morphology of corneal dendrites in herpetic epithelial keratitis and linear fissures in herpetic geometric glossitis suggest the possibility that these HSV mucosal lesions may have a common pathogenesis.
本文描述了两名免疫功能低下的疱疹性几何形舌炎患者，这是一种临床特征明显的单纯疱疹病毒1型（HSV-1）舌部感染形式。总结了疱疹性几何形舌炎的显著特征，回顾了这种HSV感染形式的临床鉴别诊断，并探讨了这些舌部病变可能的发病机制。我们的两名患者以及所有先前描述的患有这种疾病的患者，舌背均出现极度疼痛的交叉状、分支状和/或线状裂隙。症状在1至2天内迅速缓解，在开始全身使用阿昔洛韦治疗后的3至12天内，裂隙随后愈合。与疱疹性几何形舌炎的舌部病变不同，其他病症中外观相似的舌部病变通常无症状。疱疹性上皮性角膜炎中的角膜树枝状病变与疱疹性几何形舌炎中的线状裂隙形态相似，提示这些HSV黏膜病变可能具有共同的发病机制。
