Dolivo M, Beretta E, Bonifas V, Foroglou C
Brain Res. 1978 Jan 20;140(1):111-23. doi: 10.1016/0006-8993(78)90241-x.
(1) After inoculation of the pseudorabies virus in the anterior chamber of the eye of the rat, virions can be found only in the neurons of the superior cervical sympathetic ganglion and in the sensory ganglion of the fifth nerve on the inoculated side. Other nervous structures--central or peripheral--are not infected. (2) It is shown that the retrograde axonal flow carries the virus from the eye to the sympathetic neurons. (3) The ultrastructure of the infected neuron has been studied at various intervals after inoculation and at different stages of the viral replication. (4) Excised infected ganglia in vitro show a spontaneous electrophysiological activity that can be recorded on both the post- and preganglionic nerve. Such an activity has never been seen in normal excised ganglion of rat. (5) The shape and frequency of the electrophysiological discharges recorded on the postganglionic nerve have been analyzed at various intervals after inoculation. (6) Correlations established between the ultrastructure, the effect of various drugs and the electrophysiological activity permit the proposal of various hypothesis about the abnormal activity of the infected neurons.
(1) 将伪狂犬病病毒接种到大鼠眼前房后，仅在接种侧的颈上神经节神经元和三叉神经感觉神经节中可发现病毒粒子。其他神经结构——中枢或外周的——均未被感染。(2) 研究表明，逆行轴突运输将病毒从眼传至交感神经元。(3) 在接种后的不同时间间隔以及病毒复制的不同阶段，对受感染神经元的超微结构进行了研究。(4) 体外切除的受感染神经节显示出自发的电生理活动，可在节后和节前神经上记录到。这种活动在正常大鼠切除的神经节中从未见过。(5) 在接种后的不同时间间隔，对接种后在节后神经上记录到的电生理放电的形状和频率进行了分析。(6) 在超微结构、各种药物的作用与电生理活动之间建立的相关性，使得能够提出关于受感染神经元异常活动的各种假设。
