Hagemoser W A, Kluge J P, Hill H T
Can J Comp Med. 1980 Apr;44(2):192-202.
Domestic cats were inoculated orally with an Iowa isolate of pseudorabies virus. Several cats were killed at intervals of one day and tissues were examined virologically and histologically to determine the initial sites of virus penetration and replication and to evaluate the pathways traveled by the virus from the mouth to the central nervous system. Lesions were consistent in the tonsils, along the pathways of the sensory branches of the ninth and tenth cranial nerves, the tractus and nucleus solitarius and the area postrema in the medulla. Less consistent lesions in the ganglia and nuclei of the fifth cranial nerve indicated a lesser role for the passage of virus via this nerve. Nervous lesions consisted of multifocal to diffuse microgliosis, mononuclear perivascular cuffing and a mononuclear inflammatory cell infiltration with a variable number of neutrophils occasionally forming microabscesses. Virus isolations correlated well with microscopic lesions. Ultrastructurally, virions were observed within the nucleus of the neurons in the medulla. Clinical signs were similar to those previously reported. Pruritus was consistently absent. Virus was isolated consistently for the first two or three days postinoculation from oral and nasal secretions but not from secretions after three days.
给家猫口服接种一株来自衣阿华州的伪狂犬病病毒分离株。每隔一天处死几只猫，并对组织进行病毒学和组织学检查，以确定病毒穿透和复制的初始部位，并评估病毒从口腔到中枢神经系统所经过的途径。病变在扁桃体、沿第九和第十对脑神经的感觉支路径、孤束核和延髓的最后区是一致的。第五对脑神经节和核中不太一致的病变表明病毒经该神经传播的作用较小。神经病变包括多灶性至弥漫性小胶质细胞增生、单核细胞血管周围套叠以及单核炎性细胞浸润，偶尔有数量不等的中性粒细胞形成微脓肿。病毒分离与显微镜下病变相关性良好。超微结构上，在延髓神经元的细胞核内观察到病毒粒子。临床症状与先前报道的相似。一直没有瘙痒症状。接种后最初两三天，从口腔和鼻腔分泌物中能持续分离到病毒，但三天后分泌物中则分离不到。
