Field H J, Hill T J
J Gen Virol. 1975 Jan;26(1):145-8. doi: 10.1099/0022-1317-26-1-145.
Three-week-old mice were inoculated in the right ear pinna with pseuforabies virus. Ears were surgically removed at various times after inoculation and changes from the normal pathogenesis were observed. Virus replication in the ear tissue and cervical dorsal root ganglia was also monitored. Followed inoculation with a small dose of virus, local multiplication of the virus was necessary before the infection spread to the nerves. With larger infecting doses there was probably direct uptake of virus from the inoculum into the nerve endings. After these larger doses virus was first detected in the dorsal root ganglia 17 h agter infection, suggesting a retrograde axonal flow rate of at lease 1-7 mm/h.
将三周龄小鼠的右耳廓接种伪狂犬病病毒。接种后在不同时间通过手术切除耳朵，并观察与正常发病机制的变化。还监测了病毒在耳部组织和颈背根神经节中的复制情况。接种小剂量病毒后，病毒在感染扩散到神经之前需要在局部增殖。使用较大感染剂量时，病毒可能直接从接种物进入神经末梢。在这些较大剂量后，感染后17小时在背根神经节中首次检测到病毒，这表明轴突逆行流速至少为1 - 7毫米/小时。
