Mita H, Tadokoro K, Mishima T, Shida T
Clinical Research Center, National Sagamihara Hospital.
Arerugi. 1993 Aug;42(8):900-6.
We examined the clinical usefulness of three diagnostic tests including the histamine release test, RAST and prick test in determining which of a total of 349 allergens were responsible for individual cases of food hypersensitivity. The subjects were 42 children (mean 3.3 years old). When compared with the results of the offending allergen confirmed by elimination and provocation test, each diagnostic test showed a fairly good correlation in percentage agreement and negative agreement, but there was poor correlation in positive agreement (histamine release test 58.1%, RAST 62.8%, prick test 48.8%). False positive results were more frequently observed in RAST (12.6%) as compared with the histamine release test (4.0%) and prick test (2.3%). McNemar's analysis demonstrated that the histamine release test, but not RAST or the prick test, was matched the diagnosis by elimination and provocation test (alpha = 0.30). These results suggest that the histamine release test is more clinically useful than RAST or the prick test in the diagnosis of food hypersensitivity.
我们检测了三种诊断试验（包括组胺释放试验、放射性变应原吸附试验和点刺试验）在确定349种过敏原中哪些是导致个别食物过敏病例的病因时的临床实用性。受试者为42名儿童（平均年龄3.3岁）。与通过排除和激发试验确诊的致病过敏原结果相比，每项诊断试验在百分比一致性和阴性一致性方面显示出相当好的相关性，但在阳性一致性方面相关性较差（组胺释放试验为58.1%，放射性变应原吸附试验为62.8%，点刺试验为48.8%）。与组胺释放试验（4.0%）和点刺试验（2.3%）相比，放射性变应原吸附试验出现假阳性结果的频率更高（12.6%）。麦克尼马尔分析表明，组胺释放试验与通过排除和激发试验得出的诊断结果相符（α = 0.30），而放射性变应原吸附试验和点刺试验则不然。这些结果表明，在食物过敏的诊断中，组胺释放试验比放射性变应原吸附试验或点刺试验在临床上更有用。
