产后类风湿关节炎患者体内IgM类风湿因子（RF）和α2妊娠相关糖蛋白（α2 PAG）水平的变化与疾病活动度增加相关。

Changes in levels of IgM RF and alpha 2 PAG correlate with increased disease activity in rheumatoid arthritis during the puerperium.

作者信息

Quinn C, Mulpeter K, Casey E B, Feighery C F

机构信息

Department of Immunology, St. James's Hospital and Trinity College, Dublin, Ireland.

出版信息

Scand J Rheumatol. 1993;22(6):273-9. doi: 10.3109/03009749309095138.

DOI:10.3109/03009749309095138

PMID:7505481

Abstract

In this prospective study of 24 pregnant patients with rheumatoid arthritis, quiescent disease activity in 21 patients (88%) during gestation was followed by more active disease in the puerperium in 19 patients (79%). Increased disease activity was reflected in a deterioration in manual dexterity and this was found to correlate with a post-partum rise in IgM rheumatoid factor (IgM RF) (r = 0.86) and a post-partum decline in pregnancy associated alpha-2 glycoprotein (PAG) (r = 0.44). The increase in IgM RF also correlated with increased disease activity measured by a visual analogue scale (r = 0.44). Changes in IgA RF were not observed. These results suggest that PAG and IgM RF could contribute to the modulation and pathogenesis of rheumatoid arthritis during pregnancy.

摘要

在这项针对24名类风湿关节炎孕妇的前瞻性研究中，21名患者（88%）在妊娠期疾病活动静止，但产后有19名患者（79%）疾病更为活跃。疾病活动增加表现为手部灵活性恶化，且发现这与产后IgM类风湿因子（IgM RF）升高（r = 0.86）以及妊娠相关α-2糖蛋白（PAG）产后下降（r = 0.44）相关。IgM RF升高还与视觉模拟量表测量的疾病活动增加相关（r = 0.44）。未观察到IgA RF的变化。这些结果表明，PAG和IgM RF可能在妊娠期类风湿关节炎的调节和发病机制中起作用。