Grochal M, Sempińska-Edelberg E, Plewiński J
Pol J Pharmacol Pharm. 1978 Sep-Oct;30(5):659-63.
The effect of Venoruton [O-(beta-hydroxyethyl)-rutoside] on the activity of factor XIII in rat plasma was studied in vivo. The drug was administered to the animals intragastrically 6 times a week during 90 days in doses of 5 mg/100 g body weight. An about twofold increase in factor XIII activity beginning after several days of treatment and lasting for several weeks was observed. Then an attenuation of factor XIII activity down to the control level took place in spite of systematic Venoruton administration. Spectrofluorimetric determinations of factor XIII activity were confirmed by thromboelastrographic studies.
在体内研究了维脑路通[O-(β-羟乙基)-芦丁]对大鼠血浆中因子 XIII 活性的影响。在90天内，每周给动物灌胃给药6次，剂量为5mg/100g体重。观察到给药几天后因子 XIII 活性增加约两倍，并持续数周。尽管持续给予维脑路通，随后因子 XIII 活性仍衰减至对照水平。荧光分光光度法测定因子 XIII 活性得到血栓弹性图研究的证实。
