Effect of Venoruton on the factor XIII activity in rat plasma.

The effect of Venoruton [O-(beta-hydroxyethyl)-rutoside] on the activity of factor XIII in rat plasma was studied in vivo. The drug was administered to the animals intragastrically 6 times a week during 90 days in doses of 5 mg/100 g body weight. An about twofold increase in factor XIII activity beginning after several days of treatment and lasting for several weeks was observed. Then an attenuation of factor XIII activity down to the control level took place in spite of systematic Venoruton administration. Spectrofluorimetric determinations of factor XIII activity were confirmed by thromboelastrographic studies.