Palatianos G M, Dewanjee M K, Panoutsopoulos G, Kapadvanjwala M, Novak S, Sfakianakis G N
Division of Thoracic and Cardiovascular Surgery, University of Miami School of Medicine, Florida.
Pacing Clin Electrophysiol. 1994 Feb;17(2):141-5. doi: 10.1111/j.1540-8159.1994.tb01364.x.
To evaluate the thrombogenicity of transvenous silicone and polyurethane pacemaker leads, 9 of 12 anesthetized Yorkshire pigs (27-32 kg) were implanted with silicone (n = 5) or polyurethane (n = 4) pacemaker leads via a femoral vein. The remaining three pigs served as controls. All 12 pigs were injected with autologous indium-111 labeled platelets (300-420 muCi) 24 hours before anesthesia induction. The pigs were monitored for 3 hours under a gamma camera. Radioactivity in blood and lead segments was measured with a gamma counter. Platelet deposits were denser on silicone leads (441.58 +/- 915.0 to 2.19 +/- 2.07) than on polyurethane leads (1.21 +/- 1.33 to 0.27 +/- 0.14) (P > 0.05). Denser platelet deposits were detected at the tip of all leads. Density of platelet deposits declined from tip to distal segments in silicone leads. The percentage of injected platelet radioactivity in the lungs of pigs with either silastic leads (12.9 +/- 2.3%) of polyurethane leads (10.1 +/- 2.2%) was higher than in the controls (4.6 +/- 0.5%) (P < 0.05). This difference indicates thrombus formation and embolization in the lungs early after lead implantation. Thrombogenicity of polyurethane leads may be lower than that of silicone leads.
为评估经静脉植入的硅胶和聚氨酯起搏器导线的血栓形成性，12只麻醉后的约克夏猪（体重27 - 32千克）中的9只通过股静脉植入了硅胶（n = 5）或聚氨酯（n = 4）起搏器导线。其余3只猪作为对照。所有12只猪在麻醉诱导前24小时注射了自体铟 - 111标记的血小板（300 - 420微居里）。在γ相机下对猪监测3小时。用γ计数器测量血液和导线节段中的放射性。硅胶导线上的血小板沉积比聚氨酯导线上更密集（硅胶导线：441.58±915.0至2.19±2.07；聚氨酯导线：1.21±1.33至0.27±0.14）（P>0.05）。在所有导线的尖端检测到更密集的血小板沉积。硅胶导线上血小板沉积的密度从尖端到远端节段逐渐降低。植入硅胶导线（12.9±2.3%）或聚氨酯导线（10.1±2.2%）的猪肺中注入的血小板放射性百分比高于对照组（4.6±0.5%）（P<0.05）。这种差异表明导线植入后早期肺部有血栓形成和栓塞。聚氨酯导线的血栓形成性可能低于硅胶导线。
