Dewanjee M K, Rowland S M, Dewanjee P K, Kapadvanjwala M, MacGregor D C, Serafini A N, Palatianos G M, Georgiou M F, Sfakianakis G N
Department of Radiology, University of Miami, School of Medicine, FL.
Prog Clin Biol Res. 1990;355:39-48.
The dynamics of platelet deposition on CPC and HBPC was evaluated with In-111 labeled platelets (In-PLT) with a computerized gamma camera (CGC). Ten non-heparinized dogs (18-25 kg) were catheterized in both femoral arteries with 10 cm of CPC and HBPC (5 Fr., Cordis, Inc.) 24 hours post-injection of 300-420 microcuries of In-PLT, and imaged for 3 hours with gamma camera. The regional platelet deposition on three segments of catheters and puncture site was determined. The catheters were harvested and radioactivity on the catheter segments (proximal: PROX, middle: MID, distal: DIST and puncture site: PS) of both was determined. From the platelet count in blood, radioactivity in blood and segments of catheters, adjacent artery and area of artery and catheter, the platelet-density [X10(3)] (mean +/- S.D.) on catheter and artery were calculated and tabulated: (table; see text) The large standard deviation of retained platelets is due to embolization. The platelet-density and regional counts on catheter segments were lower in the HBPC than CPC. The rate of platelet-deposition was lower in the HBPC than CPC. Most of the thrombi were lost during pullout of the catheter. Both in vivo (dynamic) and in vitro studies were necessary for evaluation of CPC thrombogenicity.
使用计算机化γ相机（CGC），以铟 - 111标记的血小板（In - PLT）评估血小板在磷酸钙骨水泥（CPC）和肝素结合磷酸钙（HBPC）上的沉积动态。十只未肝素化的犬（体重18 - 25千克）在股动脉双侧插入10厘米长的CPC和HBPC（5F，Cordis公司），在注射300 - 420微居里的In - PLT后24小时，用γ相机成像3小时。测定导管三段及穿刺部位的局部血小板沉积情况。取出导管，测定两者导管段（近端：PROX、中间：MID、远端：DIST和穿刺部位：PS）的放射性。根据血液中的血小板计数、血液及导管段、相邻动脉以及动脉和导管区域的放射性，计算并列出导管和动脉上的血小板密度[X10(3)]（平均值±标准差）：（表格；见正文）保留血小板的标准差较大是由于栓塞所致。HBPC上导管段的血小板密度和局部计数低于CPC。HBPC中血小板沉积率低于CPC。大多数血栓在拔出导管过程中丢失。评估CPC的血栓形成性，体内（动态）和体外研究均有必要。
