Tarkkanen M, Wiklund T, Virolainen M, Elomaa I, Knuutila S
Department of Medical Genetics, University of Helsinki, Finland.
Genes Chromosomes Cancer. 1994 Feb;9(2):136-40. doi: 10.1002/gcc.2870090210.
Translocation t(9;22)(q22-31;q11-12) is associated with the myxoid variant of chondrosarcoma. We present here a report of a patient with a dedifferentiated grade IV chondrosarcoma, which originated from the iliac bone and contained areas of grade I chondrosarcoma. There was no evidence of myxoid differentiation. The tumor had the karyotype 46,X,-X,t(9;22)(q34;q11-12), + mar[5]/52-61,x?,2-3 min,inc[9]/46,XX[2]. It is possible that the different breakpoints in the t(9;22) may reflect different histopathologic subgroups of chondrosarcoma.
易位t(9;22)(q22 - 31;q11 - 12)与软骨肉瘤的黏液样变体相关。我们在此报告一例去分化IV级软骨肉瘤患者，该肿瘤起源于髂骨，包含I级软骨肉瘤区域。未发现黏液样分化证据。肿瘤核型为46,X,-X,t(9;22)(q34;q11 - 12), + mar[5]/52 - 61,x?,2 - 3 min,inc[9]/46,XX[2]。t(9;22)中不同的断点可能反映了软骨肉瘤不同的组织病理学亚组。
