El-Ghazaly M A, Khayyal M T
Department of Drug Radiation Research, National Centre for Radiation Research and Technology, Nasr City, Cairo, Egypt.
Drugs Exp Clin Res. 1995;21(6):229-36.
Whole body exposure to gamma radiation has been experimentally shown to exaggerate inflammatory responses and to enhance the release of mediators. A thirteen per cent aqueous extract of propolis (bee glue) was previously shown to have potent antiinflammatory activity. The present study was carried out to show whether the extract could influence the exaggerated inflammatory response in irradiated animals. Rats were exposed to acute (2 and 6 Gy) & fractionated (1 Gy/week) doses of gamma ionizing radiation. Treatment with the aqueous extract orally (5 ml/kg) before and after radiation exposure markedly reduced the exaggerated paw oedema response to carrageenan. In the acute phase of adjuvant-induced arthritis, exposure to ionizing radiation caused an increase in serum acid phosphatase level. Malondialdehyde concentration in plasma and superoxide dismutase activity in blood significantly increased. Treatment with aqueous propolis extract prior to irradiation reduced malondialdehyde concentration in plasma and normalized the serum acid phosphatase level. The extract stimulated the release of superoxide dismutase enzyme. Aqueous propolis extract could possibly be of therapeutic value in protecting against inflammatory responses induced by gamma radiation.
实验表明，全身暴露于γ辐射会加剧炎症反应并增强介质的释放。先前已表明，13%的蜂胶（蜂胶）水提取物具有强大的抗炎活性。本研究旨在表明该提取物是否能影响受辐照动物过度的炎症反应。将大鼠暴露于急性（2和6 Gy）和分次（1 Gy/周）剂量的γ电离辐射。在辐射暴露前后口服水提取物（5 ml/kg）进行治疗，可显著降低对角叉菜胶引起的过度爪肿胀反应。在佐剂性关节炎的急性期，暴露于电离辐射会导致血清酸性磷酸酶水平升高。血浆中丙二醛浓度和血液中超氧化物歧化酶活性显著增加。照射前用水溶性蜂胶提取物治疗可降低血浆中丙二醛浓度，并使血清酸性磷酸酶水平恢复正常。该提取物刺激了超氧化物歧化酶的释放。蜂胶水提取物在预防γ辐射诱导的炎症反应方面可能具有治疗价值。
