Hu Fuliang, Hepburn H R, Li Yinghua, Chen M, Radloff S E, Daya S
College of Animal Science, Zhejiang University, Hangzhou 310029, China.
J Ethnopharmacol. 2005 Sep 14;100(3):276-83. doi: 10.1016/j.jep.2005.02.044.
The anti-inflammatory effects of ethanol (EEP) and water (WSD) extracts in ICR mice and Wistar rats were analyzed. Both WSD and EEP exhibited significant anti-inflammatory effects in animal models with respect to thoracic capillary vessel leakage in mice, carrageenan-induced oedema, carrageenan-induced pleurisy, acute lung damage in rats. The mechanisms for the anti-inflammatory effects probably involve decreasing prostaglandin-E(2) (PGE(2)) and nitric oxide (NO) levels. In rats with Freund's complete adjuvant (FCA) induced arthritis, propolis extracts significantly inhibited the increase of interleukin-6 (IL-6) in inflamed tissues, but had no significant effect on levels of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma). The results are consistent with the interpretation that EEP and WSD may exert these effects by inhibiting the activation and differentiation of mononuclear macrophages.
分析了乙醇提取物（EEP）和水提取物（WSD）对ICR小鼠和Wistar大鼠的抗炎作用。WSD和EEP在动物模型中对小鼠胸毛细血管渗漏、角叉菜胶诱导的水肿、角叉菜胶诱导的胸膜炎、大鼠急性肺损伤均表现出显著的抗炎作用。抗炎作用的机制可能涉及降低前列腺素E2（PGE2）和一氧化氮（NO）水平。在弗氏完全佐剂（FCA）诱导的关节炎大鼠中，蜂胶提取物显著抑制炎症组织中白细胞介素-6（IL-6）的增加，但对白细胞介素-2（IL-2）和干扰素-γ（IFN-γ）水平无显著影响。结果与EEP和WSD可能通过抑制单核巨噬细胞的激活和分化发挥这些作用的解释一致。
