Boscaino A, Donofrio V, Tornillo L, Staibano S, De Rosa G
Institute of Pathology, 2nd Faculty of Medicine, University of Naples Federico II, Italy.
Dermatology. 1994;188(4):322-5. doi: 10.1159/000247176.
We report on a primary cutaneous rhabdoid tumour in a 14-month-old child, to the best of our knowledge, the second case in the literature. The tumour showed a multipolypoid gross appearance and classical histological features. The neoplastic cells were positive for keratin and vimentin and most were positive for proliferating cell nuclear antigen. The ultrastructural examination revealed typical intracytoplasmic aggregates of intermediate filaments. The tumour showed a very aggressive course, and the child died 5 months after the diagnosis of cerebral metastasis.
据我们所知，我们报告了一名14个月大儿童的原发性皮肤横纹肌样瘤，这是文献中的第二例。该肿瘤肉眼呈多息肉样外观，具有典型的组织学特征。肿瘤细胞角蛋白和波形蛋白呈阳性，大多数增殖细胞核抗原也呈阳性。超微结构检查显示典型的中间丝胞浆内聚集体。该肿瘤病程极具侵袭性，患儿在诊断为脑转移后5个月死亡。
