Bogdanov G N, Shmonina V M
Biol Bull Acad Sci USSR. 1978 May-Jun;5(3):367-71.
A comparative study was made of the metabolism of nucleic acids in hepatomas with a different degree of differentiation (46, 60, and 22A), liver, and regenerating liver. A direct correlation was found between the initial rate of incorporation of [14C]thymidine into DNA and the maximum growth rate of the hepatomas and regenerating liver. An increase of the specific DNA content as the hepatomas deviated from the normal liver is shown. A direct relation was found between the value of the RNA/DNA ratio and maximum growth rate of the hepatomas. A study of the catabolism of nucleic acids revealed inhibition of the breakdown of nucleic acids of hepatomas in comparison with a number of normal tissues, except liver tissues. The possible cause of these phenomena are discussed.
对不同分化程度（46、60和22A）的肝癌、肝脏及再生肝中的核酸代谢进行了比较研究。发现[14C]胸腺嘧啶核苷掺入DNA的初始速率与肝癌及再生肝的最大生长速率之间存在直接相关性。结果表明，随着肝癌偏离正常肝脏，其特异性DNA含量增加。还发现RNA/DNA比值与肝癌的最大生长速率之间存在直接关系。对核酸分解代谢的研究表明，与除肝脏组织外的许多正常组织相比，肝癌中核酸的分解受到抑制。文中讨论了这些现象的可能原因。
