Chowdhury A R, Gautam A K
National Institute of Occupational Health, Meghani Nagar, Ahmedabad, India.
J UOEH. 1994 Jun 1;16(2):145-52. doi: 10.7888/juoeh.16.145.
The effect on testicular steroidogenesis after lindane (delta-isomer of hexachlorocyclohexane) administration of 4 and 8 mg/kg, i.p. daily for 45 days to male mature rats was investigated. A significant decline in testicular weight of both test groups was observed. Cellular degeneration in Leydig cells of the 8 mg/kg treated group was conspicuous. A sharp decline in the Leydig cell's population and morphological deformation were supported by the decreased activities of testicular hyaluronidase and 3 beta delta 5-hydroxysteroid dehydrogenase. A high level of testicular cholesterol and depletion of ascorbic acid were also responsible for steroidogenic impairment in the treated groups. These impairments also led to a significant diminution in serum testosterone.
研究了对雄性成年大鼠腹腔注射林丹（六氯环己烷的δ异构体），剂量为4毫克/千克和8毫克/千克，每日一次，持续45天，对睾丸类固醇生成的影响。观察到两个试验组的睾丸重量均显著下降。在8毫克/千克处理组的睾丸间质细胞中，细胞变性明显。睾丸透明质酸酶和3βδ5-羟基类固醇脱氢酶活性降低，支持了睾丸间质细胞数量的急剧下降和形态变形。治疗组中高水平的睾丸胆固醇和抗坏血酸的消耗也导致了类固醇生成受损。这些损伤还导致血清睾酮显著减少。
