Camí J, Lamas X, Farré M
Department of Pharmacology and Toxicology, Institut Municipal d'Investigació Mèdica, Universitat Autònoma, Barcelona, Spain.
Drugs. 1994;47 Suppl 1:39-43. doi: 10.2165/00003495-199400471-00007.
The opioid agonist and antagonist properties of tramadol were assessed in 6 male opioid-dependent volunteers enrolled in a methadone maintenance programme. Subjects participated in 3 experimental sessions in which the effects of intramuscular tramadol 100 and 300 mg and placebo were evaluated. Tramadol neither produced morphine-like effects nor precipitated a withdrawal syndrome; its subjective, behavioural and physiological effects were not different from those of placebo. Although the results of this study suggest that tramadol has a low abuse liability in opioid-dependent subjects, higher doses should be tested to confirm these data.
在6名参加美沙酮维持治疗计划的男性阿片类药物依赖志愿者中评估了曲马多的阿片类激动剂和拮抗剂特性。受试者参加了3次实验，评估了肌肉注射100毫克和300毫克曲马多以及安慰剂的效果。曲马多既未产生吗啡样效应，也未引发戒断综合征；其主观、行为和生理效应与安慰剂无异。尽管本研究结果表明曲马多在阿片类药物依赖受试者中的滥用可能性较低，但仍应测试更高剂量以证实这些数据。
