Ozeretskovskaia N N, Legon'kov Iu A, Shcherbakov A M, Suntsov S N, Sabgaĭda T P, Grigorian S S, Gervazieva V B
Med Parazitol (Mosk). 1993 Mar-Apr(2):10-4.
The correlations between blood eosinophils, serum immunoglobulins (Ig), circulating immune complexes (CIC) content, alpha- and gamma-interferon (IFN) production and HLA class I antigens were analyzed in 33 patients with hydatid disease aged 37.5 +/- 1.5 years. Direct correlation between the activity of gamma-IFN production, blood eosinophils, IgG and specific IgE content was found in patients with multiple pulmonary damage. In this group the high level of CIC correlated with the high content of IgG and specific IgE. In patients with solitary and multiple cysts in the liver in spite of high alpha- and gamma-IFN production the levels of total and specific IgE were low, IgG and CIC contents were moderate and eosinophils percent was low. In patients with combined damage of the liver and multiple cysts in the abdominal cavity high CIC production correlated directly with high total IgE content. In the total group of patients percent of HLA B5 carriers was significantly higher than in controls: 36.6 and 14.7 respectively (R = 0.01 after Fischer) that correlated with comparatively active gamma-IFN production in patients with the pulmonary and the liver cysts. The possible explanation of the different immune response in patients with the different localisation of the parasite cysts are discussed.
对33例年龄为37.5±1.5岁的包虫病患者的血液嗜酸性粒细胞、血清免疫球蛋白（Ig）、循环免疫复合物（CIC）含量、α和γ干扰素（IFN）产生情况与HLAⅠ类抗原之间的相关性进行了分析。在有多处肺部损害的患者中，发现γ干扰素产生活性、血液嗜酸性粒细胞、IgG和特异性IgE含量之间存在直接相关性。在该组中，CIC的高水平与IgG和特异性IgE的高含量相关。在肝脏有单个和多个囊肿的患者中，尽管α和γ干扰素产生水平较高，但总IgE和特异性IgE水平较低，IgG和CIC含量中等，嗜酸性粒细胞百分比低。在肝脏合并腹腔多个囊肿损害的患者中，高CIC产生与高总IgE含量直接相关。在全部患者组中，HLA B5携带者的百分比显著高于对照组，分别为36.6%和14.7%（费舍尔检验后R=0.01），这与肺囊肿和肝囊肿患者中相对活跃的γ干扰素产生相关。文中讨论了寄生虫囊肿不同定位患者免疫反应不同的可能原因。
