Suntsov S N, Ozeretskovskaia N N, Grigorian S S, Shcherbakov A M, Ershov F I
Med Parazitol (Mosk). 1990 Nov-Dec(6):43-4.
In 11 patients with Echinococcus multilocularis infection the blood levels of alpha-interferon (alpha-IF) and gamma-interferon (gamma-IF) were measured using vesical stomatitis virus culture. In patients with the disease the contents of alpha- and gamma-IF were significantly (p less than 0.01) lower than in healthy controls: 392 +/- 101.6 and 101.6 +/- 20.9 U/ml and 1024 +/- 83.2 and 187 +/- 16.9 U/ml, respectively. The lower levels of alpha- and gamma-IF were found in patients with multiorgan damages including the lungs, as compared with the liver and abdomen infestation: alpha-IF 160 +/- 56.6, gamma-IF 88 +/- 24.0 and 525.7 +/- 124.3 and 109 +/- 18.3 (p less than 0.01), respectively. The similar data have been found in patients with hydatid disease (S. N. Suntsov et al., 1990). After 5 to 6 courses of mebendazole therapy in a dose of 50 mg/kg body weight dai y for 30 days with 30-day intervals there was a tendency to a slight elevation of cytokines levels (S. N. Suntsov et al., 1990), as seen in hydatid disease. The estimation of IF levels in multilocular echinococcosis infection may be of prognostic value and perhaps for the evaluation of the efficacy of surgical and chemotherapeutic treatment.
对11例泡型棘球蚴感染患者，采用水疱性口炎病毒培养法检测其血液中α-干扰素（α-IF）和γ-干扰素（γ-IF）水平。患病患者体内α-IF和γ-IF含量显著低于健康对照（p<0.01）：分别为392±101.6和101.6±20.9U/ml以及1024±83.2和187±16.9U/ml。与肝和腹部感染相比，多器官受损（包括肺部）患者的α-IF和γ-IF水平更低：α-IF分别为160±56.6和525.7±124.3，γ-IF分别为88±24.0和109±18.3（p<0.01）。泡型包虫病患者也有类似数据（S.N. Suntsov等，1990）。以50mg/kg体重的剂量每日服用甲苯达唑，每30天为一个疗程，间隔30天，共进行5至6个疗程后，细胞因子水平有轻微升高的趋势（S.N. Suntsov等，1990），泡型包虫病患者也是如此。检测泡型棘球蚴病感染中的IF水平可能具有预后价值，或许还可用于评估手术和化疗的疗效。
