Suntsov S N, Ozeretskovskaia N N, Grigorian S S, Shcherbakov A M
Med Parazitol (Mosk). 1990 Jul-Aug(4):27-9.
In 51 patients with Echinococcus granulosus infection, blood IF alpha and IF gamma levels were measured using vesicular stomatitis virus culture. In patients with progressing disease, the IF alpha and IF gamma levels were significantly lower than in the benign form of the disease--144 +/- 28.8 and 51.6 +/- 10.1 U/ml, respectively (in healthy controls the levels were 1024 +/- 28.8 and 187.7 +/- 16.9 U/ml). The lowest levels of IF alpha and IF gamma were found in patients with primary localization of cysts in the lungs and multiorgan damages affecting the lungs--160 +/- 38.5 and 44.4 +/- 13.5 U/ml; 146.7 +/- 80.1 and 89.5 +/- 19.2 U/ml, respectively. After 5-6 thirty-day courses of mebendazole therapy (50 mg/kg body weight) at 30-day intervals, the average levels of IF alpha and IF gamma were 4 and 5 times higher. Measurement of IF levels in echinococcosis may be of prognostic value for the estimation of the efficacy of surgical and/or specific treatment.
对51例细粒棘球蚴感染患者，采用水疱性口炎病毒培养法检测血液中的干扰素α（IFα）和干扰素γ（IFγ）水平。病情进展的患者，其IFα和IFγ水平显著低于疾病的良性形式，分别为144±28.8 U/ml和51.6±10.1 U/ml（健康对照者的水平分别为1024±28.8 U/ml和187.7±16.9 U/ml）。IFα和IFγ水平最低的患者为囊肿原发于肺部且多器官受累影响肺部的患者，分别为160±38.5 U/ml和44.4±13.5 U/ml；以及146.7±80.1 U/ml和89.5±19.2 U/ml。在以30天为间隔进行5 - 6个疗程、每次剂量为50 mg/kg体重的甲苯达唑治疗后，IFα和IFγ的平均水平升高了4至5倍。检测包虫病中的IF水平对于评估手术和/或特异性治疗的疗效可能具有预后价值。
