Casalone R, Portentoso P, Granata P, Minelli E, Righi R, Meroni E, Pozzi E, Chiaravalli A M
Biologia Generale e Genetica Medica, Università di Pavia, Italy.
Cancer Genet Cytogenet. 1993 Jul 15;68(2):126-30. doi: 10.1016/0165-4608(93)90008-a.
Cytogenetic studies of benign prostatic hyperplasia (BHP) are scarce. We analyzed primary cell cultures obtained from biopsies of prostatic tissues from 10 patients (mean age: 60.7 years) with histologic diagnosis of BHP to compare the eventual chromosome changes with those reported in prostatic adenocarcinoma. Clonal chromosome abnormalities were noted in five of the 10 cases, with loss of Y chromosome in all. In one case, a clonal t(1;20) was observed with a -Y clone. Different numerical and structural sporadic abnormalities were evident in eight. Chromosome 1 was the chromosome most frequently involved in sporadic rearrangements. We concluded that -Y is a frequent nonrandom chromosome abnormality in BHP in this sample of patients. Immunohistochemical studies showed that loss of Y occurs in fibroblasts and not in epithelial cells; therefore, this anomaly is not related to cancer development.
关于良性前列腺增生（BHP）的细胞遗传学研究较少。我们分析了从10例组织学诊断为BHP的患者（平均年龄：60.7岁）的前列腺组织活检中获得的原代细胞培养物，以比较最终的染色体变化与前列腺腺癌中报道的变化。10例中有5例出现克隆性染色体异常，均有Y染色体丢失。在1例中，观察到一个带有-Y克隆的克隆性t(1;20)。8例出现不同的数值和结构散发性异常。1号染色体是散发性重排中最常受累的染色体。我们得出结论，在该患者样本中，-Y是BHP中常见的非随机染色体异常。免疫组织化学研究表明，Y染色体丢失发生在成纤维细胞而非上皮细胞中；因此，这种异常与癌症发展无关。
