Sohni Y R, Mutangadura-Mhlanga T, Kale P G
Department of Biology, Alabama Agricultural and Mechanical University, Normal 35762.
Mutat Res. 1994 Aug;322(2):133-40. doi: 10.1016/0165-1218(94)00021-2.
Eight plants traditionally used as medicines in Zimbabwe were evaluated for mutagenicity. The required plant parts were dried, powdered and extracted in a Soxhlet apparatus with distilled water. The extracts were tested using Salmonella typhimurium strains TA97a, TA98, TA100 and TA102. The results indicate five of these extracts are nonmutagenic in the assay while three of the extracts were found to be mutagenic. The three plant extracts, namely those of Combretum erythrophyllum, Gnidia kraussiana and Barlerii randii, were found to be mutagenic to strain TA102. Furthermore, the extract of C. erythrophyllum was also mutagenic to strain TA100. The presence of S9 mix appeared to diminish the mutagenicity of the extracts except in the case of C. erythrophyllum, the mutagenicity of which was enhanced in strain TA100. These results assume importance in view of the fact that these plants are used as therapeutic agents.
对津巴布韦传统上用作药物的8种植物进行了致突变性评估。将所需的植物部分干燥、研磨并在索氏提取器中用蒸馏水提取。使用鼠伤寒沙门氏菌菌株TA97a、TA98、TA100和TA102对提取物进行测试。结果表明，其中5种提取物在该试验中无致突变性，而3种提取物具有致突变性。发现三种植物提取物，即红果风车子、克氏裸蒴和兰氏假杜鹃的提取物对TA102菌株具有致突变性。此外，红果风车子的提取物对TA100菌株也具有致突变性。S9混合物的存在似乎降低了提取物的致突变性，但红果风车子除外，其在TA100菌株中的致突变性增强。鉴于这些植物被用作治疗剂，这些结果具有重要意义。
