药用植物可食厚皮树（Lannea edulis (Sond.) Engl.）和光叶山檨子（Monotes glaber Sprague.）提取物诱导沙门氏菌的移码突变。

Frameshift mutations in Salmonella induced by the extracts of medicinal herbs Lannea edulis (Sond.) Engl. and Monotes glaber Sprague.

作者信息

Sohni Y R, Davis C L, DesChamps A B, Kale P G

机构信息

Department of Biology, Alabama A&M University, Normal 35762.

出版信息

Environ Mol Mutagen. 1995;25(1):77-82. doi: 10.1002/em.2850250111.

DOI:10.1002/em.2850250111

PMID:7875129

Abstract

Lannea edulis and Monotes glaber have been prescribed for various affectations in the traditional medical practice of Zimbabwe and other parts of Africa. Mutagenicity testing using Salmonella typhimurium strains TA97a, TA98, and TA100, indicated that the aqueous extracts of these plants induced frameshift mutations in Salmonella. The extract of L. edulis displayed marginal mutagenicity in strain TA97a while that of M. glaber showed a significant dose-dependent mutagenicity in both strains TA97a and TA98. There was no mutagenic effect observed in strain TA100. Two other plant extracts, those of Lannea discolor and Dolichos kilimandscharicus, were nonmutagenic in all three strains.

摘要

在津巴布韦和非洲其他地区的传统医学实践中，食用榄仁（Lannea edulis）和光腺豆（Monotes glaber）被用于治疗各种病症。使用鼠伤寒沙门氏菌菌株TA97a、TA98和TA100进行的致突变性测试表明，这些植物的水提取物可在沙门氏菌中诱导移码突变。食用榄仁的提取物在TA97a菌株中表现出轻微的致突变性，而光腺豆的提取物在TA97a和TA98菌株中均表现出显著的剂量依赖性致突变性。在TA100菌株中未观察到致突变作用。另外两种植物提取物，即变色榄仁（Lannea discolor）和乞力马扎罗山扁豆（Dolichos kilimandscharicus）的提取物，在所有三种菌株中均无致突变性。