Marco J, Hedo J A, Villanueva M L
J Clin Endocrinol Metab. 1978 Jan;46(1):140-5. doi: 10.1210/jcem-46-1-140.
In this work we have evaluated the effects of blood sugar changes on human pancreatic polypeptide (hPP) secretion in young, healthy subjects. Mean fasting hPP level was 74 +/- 5 (SEM) pg/ml (n = 53). Insulin-induced as well as tolbutamide-induced hypoglycemia clearly provoked hPP secretion (peaks: 1201 +/- 370 pg/ml, P = 0.03, and 520 +/- 112 pg/ml, P = 0.005, respectively). In contrast, the induction of hyperglycemia by intravenous glucose infusion (0.6 g/min) elicited a significant depression of circulating hPP (37-49% of basal values); discontinuing the infusion resulted in an increase of hPP concentrations (peak: 519 +/- 141 pg/ml, P = 0.018), which coincided with the decline of blood sugar to sub-baseline levels. Glucose as an intravenous bolus (0.33 g/kg) also induced a fall in plasma hPP. Glucose ingestion (1.75 g/kg) was followed by a small and short lived elevation of hPP (154 +/- 34 pg/ml at 15 min, P = 0.04) and by a marked rise during the late hypoglycemic phase of the test (538 +/- 168 pg/ml at 120 min, P = 0.028). Finally, after intravenous arginine, a delayed increase of hPP values was observed, occurring subsequently to the plasma glucose drop. The foregoing data indicate that experimental fluctuations in glycemia inversely affect hPP secretion. Nevertheless, this relationship does not necessarily mean that hPP should be directly implicated in glucose homeostasis.
在这项研究中，我们评估了血糖变化对年轻健康受试者人胰多肽（hPP）分泌的影响。空腹时hPP的平均水平为74±5（SEM）pg/ml（n = 53）。胰岛素诱导以及甲苯磺丁脲诱导的低血糖明显刺激了hPP的分泌（峰值分别为：1201±370 pg/ml，P = 0.03；520±112 pg/ml，P = 0.005）。相比之下，静脉输注葡萄糖（0.6 g/min）诱导的高血糖导致循环中hPP显著降低（为基础值的37 - 49%）；停止输注导致hPP浓度升高（峰值：519±141 pg/ml，P = 0.018），这与血糖降至基线以下水平同时发生。静脉推注葡萄糖（0.33 g/kg）也导致血浆hPP下降。摄入葡萄糖（1.75 g/kg）后，hPP出现小幅短暂升高（15分钟时为154±34 pg/ml，P = 0.04），并在试验后期低血糖阶段显著升高（120分钟时为538±168 pg/ml，P = 0.028）。最后，静脉注射精氨酸后，观察到hPP值延迟升高，发生在血糖下降之后。上述数据表明血糖的实验性波动对hPP分泌有反向影响。然而，这种关系并不一定意味着hPP应直接参与葡萄糖稳态调节。
