水浸应激诱导大鼠热休克蛋白并预防蛙皮素诱导的胰腺炎

Induction of heat shock protein and prevention of caerulein-induced pancreatitis by water-immersion stress in rats.

作者信息

Otaka M, Itoh H, Kuwabara T, Zeniya A, Fujimori S, Otani S, Tashima Y, Masamune O

机构信息

First Department of Internal Medicine, Akita University School of Medicine, Japan.

出版信息

Int J Biochem. 1994 Jun;26(6):805-11. doi: 10.1016/0020-711x(94)90110-4.

DOI:10.1016/0020-711x(94)90110-4

PMID:7520397

Abstract

Water-immersion stress is known to be involved in the development of hemorrhagic pancreatitis in caerulein-induced pancreatitis, when the stress is given following caerulein injection. The effects of pre-treatment with water-immersion to caerulein-induced pancreatitis were investigated in this study. 1. A 60-kDa heat shock protein was induced by pre-treatment with water-immersion stress in the pancreas. 2. Intra-peritoneal injection of caerulein (40 micrograms/kg) induced acute pancreatitis in rats without pre-treatment with water-immersion. However, when the rats were pre-treated with water-immersion, acute pancreatitis was not developed and no change of serum amylase levels was observed by i.p. injection of caerulein.

摘要

已知在蛙皮素诱导的胰腺炎中，若在注射蛙皮素后施加水浸应激，这种应激会参与出血性胰腺炎的发展。本研究调查了水浸预处理对蛙皮素诱导的胰腺炎的影响。1. 水浸应激预处理可在胰腺中诱导出一种60 kDa的热休克蛋白。2. 腹腔注射蛙皮素（40微克/千克）可在未进行水浸预处理的大鼠中诱发急性胰腺炎。然而，当大鼠进行水浸预处理后，腹腔注射蛙皮素未引发急性胰腺炎，且血清淀粉酶水平未出现变化。