水浸应激诱导大鼠胰腺中60 kDa热休克蛋白的产生。
Induction of a 60-kDa heat shock protein in rat pancreas by water-immersion stress.
作者信息
Otaka M, Itoh H, Kuwabara T, Zeniya A, Fujimori S, Tashima Y, Masamune O
机构信息
First Department of Internal Medicine, Akita University School of Medicine, Japan.
出版信息
Int J Biochem. 1993 Dec;25(12):1769-73.
PMID:7907997
Abstract
- In this study, expression of a 60-kDa heat shock protein in rat pancreas was investigated before and after water-immersion stress, which has been known as an exacerbation factor of caerulein-induced pancreatitis in rats, by Western blot. 2. A 60-kDa heat shock protein increased after water-immersion stress in both soluble and insoluble fractions of the pancreas. 3. Serum amylase level and pancreas weight did not increase after water-immersion. 4. No pathologic alteration was observed in the pancreas after water-immersion.
摘要
- 在本研究中，通过蛋白质印迹法对大鼠胰腺中60 kDa热休克蛋白在水浸应激前后的表达进行了研究，水浸应激是已知的大鼠蛙皮素诱导胰腺炎的加重因素。2. 胰腺的可溶性和不溶性部分中，60 kDa热休克蛋白在水浸应激后均增加。3. 水浸后血清淀粉酶水平和胰腺重量未增加。4. 水浸后胰腺未观察到病理改变。
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