Yamaguchi O, Irisawa C, Baba K, Ogihara M, Yokota T, Shiraiwa Y
Department of Urology, Fukushima Medical College.
Tohoku J Exp Med. 1994 Mar;172(3):291-3. doi: 10.1620/tjem.172.291.
C3H mice bearing subcutaneously transplanted mouse bladder carcinoma (MBT-2) were treated with intramuscular injection of bleomycin followed by local delivery of electric pulses at the tumor site. The tumors markedly reduced and even disappeared for several days after this treatment. Neither electric pulses nor bleomycin administration alone showed a significant inhibitory effect on the tumor growth. Thus, it is demonstrated that in mouse bladder tumor the antitumor effect of bleomycin can be considerably potentiated by local electric pulses.
对皮下移植了小鼠膀胱癌（MBT - 2）的C3H小鼠进行治疗，先肌肉注射博来霉素，然后在肿瘤部位进行局部电脉冲处理。治疗后肿瘤明显缩小，甚至在数天内消失。单独的电脉冲或博来霉素给药均未显示出对肿瘤生长的显著抑制作用。因此，证明在小鼠膀胱肿瘤中，局部电脉冲可显著增强博来霉素的抗肿瘤作用。
