Quiroga J A, Herrero M, Castillo I, Navas S, Pardo M, Carreño V
Hepatology Unit, Fundación Jiménez Díaz, Madrid, Spain.
J Infect Dis. 1994 Sep;170(3):669-73. doi: 10.1093/infdis/170.3.669.
IgM anti-hepatitis C virus (HCV) and HCV RNA were longitudinally tested for 4.0-8.7 years in 40 patients with chronic HCV infection. Patients in disease remission usually lost IgM anti-HCV and HCV RNA, but most patients experiencing disease reactivation had increased levels of the IgM antibody or it reappeared before the biochemical relapse, even when HCV RNA was undetectable. IgM anti-HCV was detectable in most patients with ongoing viral replication and persistent liver disease. Despite long-term disease remission, IgM anti-HCV may persist and be detectable with or without evidence of serum HCV RNA; this indicates a possible disease reactivation, which could occur after several years of sustained transaminase normalization. Detection of IgM anti-HCV in chronic hepatitis C indicates an active immune response to persistent viral infection and should, therefore, be considered as a sensitive marker of active HCV replication and HCV-associated liver disease.
对40例慢性丙型肝炎病毒（HCV）感染者进行了4.0至8.7年的IgM抗HCV和HCV RNA纵向检测。病情缓解的患者通常会失去IgM抗HCV和HCV RNA，但大多数病情复发的患者IgM抗体水平升高或在生化复发前重新出现，即使HCV RNA检测不到。大多数持续病毒复制和持续性肝病患者可检测到IgM抗HCV。尽管疾病长期缓解，但IgM抗HCV可能持续存在，无论有无血清HCV RNA证据均可检测到；这表明可能发生疾病复发，可能在转氨酶持续正常数年之后出现。慢性丙型肝炎中IgM抗HCV的检测表明对持续性病毒感染有活跃的免疫反应，因此应被视为活跃HCV复制和HCV相关肝病的敏感标志物。
