来自HIV感染患者的细胞毒性T淋巴细胞（CTL）对gag蛋白的多特异性和异质性识别：除MHC外的其他因素控制表位特异性。
Multispecific and heterogeneous recognition of the gag protein by cytotoxic T lymphocytes (CTL) from HIV-infected patients: factors other than the MHC control the epitopic specificities.
作者信息
Buseyne F, Janvier G, Fleury B, Schmidt D, Rivière Y
机构信息
Unité de Virologie et d'Immunologie Cellulaire, URA CNRS 1157, Institut Pasteur, Paris, France.
出版信息
Clin Exp Immunol. 1994 Sep;97(3):353-60. doi: 10.1111/j.1365-2249.1994.tb06094.x.
Abstract
The HIV gag polyprotein is a major target for recognition by CTL in infected humans. Using recombinant vaccinia viruses (rVV) expressing truncations of the p24gag, and the p18gag, p15gag and HIV-2 p56gag proteins, the characterization of epitope regions recognized by in vitro-stimulated peripheral blood mononuclear cells (PBMC) from 18 infected patients has been studied. The gag-specific response of most individuals is polyclonal and multispecific, and interindividual variations between target epitope regions were frequently observed, despite shared MHC alleles. As CTL may play an important role in the control of HIV replication in infected hosts, these results have important implications for designing vaccine strategies.
摘要
HIV gag多聚蛋白是受感染人类中CTL识别的主要靶标。利用表达p24gag截短体以及p18gag、p15gag和HIV-2 p56gag蛋白的重组痘苗病毒（rVV），对18名受感染患者体外刺激的外周血单个核细胞（PBMC）识别的表位区域特征进行了研究。大多数个体的gag特异性反应是多克隆和多特异性的，尽管共享MHC等位基因，但仍经常观察到靶表位区域之间的个体差异。由于CTL可能在受感染宿主中控制HIV复制方面发挥重要作用，这些结果对设计疫苗策略具有重要意义。
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