Weide R, Heymanns J, Köppler H, Tiemann M, Huss B, Pflüger K H, Havemann K
Department of Hematology, Philipps University, Marburg, Germany.
Ann Hematol. 1994 Sep;69(3):117-9. doi: 10.1007/BF01695691.
Severe neutropenia is a common feature in patients with T-large granular lymphocytic (LGL) leukemia. Neutropenia often causes severe infections and septicemia, thus representing a major cause of morbidity and mortality in this disease. We have treated two outpatients with T-LGL leukemia who had severe neutropenia (neutrophils < 0.2 x 10(9)/l) successfully with G-CSF (5 micrograms/kg daily, s.c.). After 10 days of treatment the neutrophil count was within the normal range and a severe oral infection healed rapidly. We conclude that G-CSF therapy is able to normalize the neutrophil count in T-LGL leukemia within a few days and that it can be used to treat severe infections in these patients even on an outpatient basis.
严重中性粒细胞减少是T大颗粒淋巴细胞（LGL）白血病患者的常见特征。中性粒细胞减少常导致严重感染和败血症，因此是该疾病发病和死亡的主要原因。我们成功地用粒细胞集落刺激因子（G-CSF，每日5微克/千克，皮下注射）治疗了两名患有严重中性粒细胞减少（中性粒细胞<0.2×10⁹/升）的T-LGL白血病门诊患者。治疗10天后，中性粒细胞计数恢复正常，严重的口腔感染迅速愈合。我们得出结论，G-CSF疗法能够在几天内使T-LGL白血病患者的中性粒细胞计数恢复正常，并且即使在门诊患者中也可用于治疗这些患者的严重感染。
