Brouet J C, Sasportes M, Flandrin G, Preud'Homme J L, Seligmann M
Lancet. 1975 Nov 8;2(7941):890-3. doi: 10.1016/s0140-6736(75)92127-3.
Eleven patients with chronic lymphocytic leukaemia of T-cell origin are reported. The identification of the leukaemic cells was performed with seven different membrane markers for either T or B lymphocytes. The reactivity of the leukaemic T cells with three different heteroantisera to T cells differed from patient to patient but was homogeneous in individual cases. This finding suggests that the leukaemic lymphocytes belonged to a single subset of T cells. These lymphocytes responded to allogeneic cells in some of these patients. In contrast, stimulation by non-specific mitogens was poor in most patients. Two patients were affected with the prolymphocytic type of chronic lymphocytic leukaemia, but a characteristic clinical and haematological pattern was found in nine patients. The blood and marrow infiltration was moderate and the proliferating T lymphocytes had a high content of lysosomal enymes in all patients and cytoplasmic granules in six cases. Other unusual features included massive splenomegaly (five patients), skin lesions (four patients), and major neutropenia (four patients).
报告了11例T细胞起源的慢性淋巴细胞白血病患者。使用针对T或B淋巴细胞的7种不同膜标记物对白血病细胞进行鉴定。白血病T细胞与三种不同的T细胞异种抗血清的反应性因患者而异，但在个别病例中是一致的。这一发现表明白血病淋巴细胞属于T细胞的单个亚群。在其中一些患者中，这些淋巴细胞对同种异体细胞有反应。相比之下，大多数患者对非特异性有丝分裂原的刺激反应较差。两名患者患有原淋巴细胞型慢性淋巴细胞白血病，但在9名患者中发现了特征性的临床和血液学模式。所有患者的血液和骨髓浸润均为中度，增殖的T淋巴细胞溶酶体酶含量高，6例有细胞质颗粒。其他不寻常的特征包括巨脾（5例）、皮肤病变（4例）和严重中性粒细胞减少（4例）。
