Bret-Dibat J L, Kent S, Couraud J Y, Creminon C, Dantzer R
INSERM U394, Bordeaux, France.
Neurosci Lett. 1994 May 23;173(1-2):205-9. doi: 10.1016/0304-3940(94)90184-8.
To assess whether peripheral immune stimuli activate sensory afferents at behaviorally active doses, we measured the effects of lipopolysaccharide (LPS) on the levels of sensory neuropeptides in the spinal cord. LPS (10 micrograms/mouse i.p.) increased the levels of substance P, neurokinin A, and calcitonin gene-related peptide in the spinal cord, the maximum being observed 1 hr post-injection. Pretreatment with indomethacin at a dose (5 mg/kg i.p.) which completely blocked the decrease in food-motivated behavior induced by LPS abrogated this effect.
为了评估外周免疫刺激在行为活性剂量下是否激活感觉传入神经，我们测量了脂多糖（LPS）对脊髓中感觉神经肽水平的影响。LPS（10微克/小鼠，腹腔注射）增加了脊髓中P物质、神经激肽A和降钙素基因相关肽的水平，注射后1小时观察到最大值。以完全阻断LPS诱导的食物驱动行为减少的剂量（5毫克/千克，腹腔注射）的吲哚美辛预处理消除了这种效应。
