Kuyucak S, Chung S H
Department of Theoretical Physics, Research School of Physical Sciences, Australian National University, Canberra.
Biophys Chem. 1994 Sep;52(1):15-24. doi: 10.1016/0301-4622(94)00034-4.
Temperature is a key parameter in the description of any physical system. Experimental study of the temperature dependence of conductivity is very valuable in building and testing theoretical models. This fact does not appear to be fully appreciated and exploited in the study of ionic channels of biological membranes owing in part to the lack of an adequate theory for the temperature dependence of conductivity in electrolyte solutions. To redress this imbalance, and to encourage further temperature-dependence studies in ionic channels, we first give explicit expressions for the conductivity of ions in electrolyte solutions in terms of the microscopic parameters of the liquid. We then propose that the dynamics of ion transport in membrane channels are similar to that in bulk electrolyte solutions, except that ions permeating the pore need to surmount a potential barrier, the height of which can be deduced experimentally. Finally, we use our model to analyze the conductance-temperature relationships obtained in two types of single ionic channels.
温度是描述任何物理系统的关键参数。对电导率温度依赖性的实验研究对于构建和测试理论模型非常有价值。由于缺乏关于电解质溶液电导率温度依赖性的适当理论，这一事实在生物膜离子通道的研究中似乎没有得到充分认识和利用。为了纠正这种不平衡，并鼓励在离子通道中进一步开展温度依赖性研究，我们首先根据液体的微观参数给出电解质溶液中离子电导率的明确表达式。然后我们提出，膜通道中离子传输的动力学与本体电解质溶液中的相似，只是渗透孔隙的离子需要克服一个势垒，其高度可以通过实验推导得出。最后，我们用我们的模型分析了在两种单离子通道中获得的电导-温度关系。
