Goldberg T E, Weinberger D R
Clinical Brain Disorders Branch, National Institute of Mental Health Neurosciences Center, St. Elizabeths, Washington, D.C. 20032.
J Clin Psychiatry. 1994 Sep;55 Suppl B:88-90.
Clozapine has proved effective in alleviating a wide range of psychiatric symptoms in schizophrenia. Its effects on cognitive function in schizophrenia are more variable. Clozapine appears to have a salutary effect on some aspects of attention, response speed, and fluency, whereas it appears to have a mild but adverse effect on visual memory and some executive functions. This profile may be related to the affinity of clozapine for dopaminergic type I and muscarinic receptors and relative lack of affinity for dopaminergic type II receptors.
氯氮平已被证明在缓解精神分裂症的多种精神症状方面有效。其对精神分裂症认知功能的影响则更具变异性。氯氮平似乎在注意力、反应速度和流畅性的某些方面具有有益作用，而在视觉记忆和一些执行功能方面似乎有轻微但不良的影响。这种情况可能与氯氮平对I型多巴胺能受体和毒蕈碱受体的亲和力以及对II型多巴胺能受体相对缺乏亲和力有关。
