De Miguel E, Arnalich F, Tato E, Vázquez J J, Gijón-Baños J, Hernanz A
Department of Medicine, Hospital La Paz, Madrid, Spain.
Neurosci Lett. 1994 Jun 20;174(2):185-7. doi: 10.1016/0304-3940(94)90017-5.
The effect of gold salt therapy on substance P immunoreactivity levels in plasma and synovial fluid was studied in 42 patients with rheumatoid arthritis. Decreased levels of synovial fluid substance P, although not statistically significant, were found in rheumatoid patients who were currently receiving gold therapy when compared to either those patients previously treated or to those who never received this therapy. In addition, we found that patients who received more than 1000 mg of gold salts had significantly lower levels of substance P in synovial fluid than those treated with lower doses. Our results, therefore, seem to support the hypothesis that gold salts appear to be slow-acting neurotoxic drugs that significantly decrease the intrasynovial concentrations of substance P, a well-known inflammatory neuropeptide, in arthritis patients.
对42例类风湿性关节炎患者研究了金盐疗法对血浆和滑液中P物质免疫反应水平的影响。与既往接受过治疗的患者或从未接受过该疗法的患者相比，目前正在接受金疗法的类风湿患者滑液中P物质水平有所降低，尽管无统计学意义。此外，我们发现接受超过1000毫克金盐治疗的患者滑液中P物质水平明显低于接受较低剂量治疗的患者。因此，我们的结果似乎支持这样一种假设，即金盐似乎是作用缓慢的神经毒性药物，可显著降低关节炎患者滑膜内著名的炎性神经肽P物质的浓度。
