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[食管癌和贲门癌的外科治疗结果]

[Results of surgical therapy in esophagus and cardia carcinoma].

作者信息

Graf M, von Flüe M, Herzog U, Ackermann C, Tondelli P

机构信息

Allgemeinchirurgische Abteilung, St. Claraspital, Basel.

出版信息

Schweiz Med Wochenschr. 1994 Oct 29;124(43):1900-4.

PMID:7526449
Abstract

Surgery for carcinoma of the esophagus and cardia represents potentially curative therapy in early stage of tumor. In the advanced stage of tumor palliation is the only remaining therapeutic aim. In a retrospective study covering the period 1984-1992 we analyzed 51 patients who underwent surgery for esophageal or cardia cancer to determine whether palliation by surgery is feasible. We also analyzed morbidity and mortality of peri- and postoperative complications. In 88% we carried out standard esophagectomy consisting of abdomino-thoracic access, gastric interposition with thoracic anastomosis and extramucous pyloromyotomy. In the light of postresection histology, 53% of the operations were potentially curative (UICC stage I and II) [1], 47% palliative (UICC stage III and IV) [1]. Perioperative 30-days mortality was nil, perioperative 30-days morbidity 11% (3 patients developed pneumonia postoperatively, 2 patients with cervical anastomosis developed dehiscence of anastomosis which in both cases healed completely with conservative therapy, while a further patient with cervical anastomosis suffered persistent paralysis of the recurrent nerve. All patients were fully able to feed themselves at the time of discharge. 43% of patients had recurrent dysphagia and 24% underwent endoscopic dilatation. Three-year survival was 26%. From these results it may be concluded that esophageal resection represents either good palliation with low morbidity for the majority of patients with non-resectable carcinoma of the esophagus or potentially curative therapy with low morbidity in early stage of tumor.

摘要

食管癌和贲门癌手术在肿瘤早期代表着潜在的治愈性治疗。在肿瘤晚期,缓解症状是唯一剩余的治疗目标。在一项涵盖1984年至1992年期间的回顾性研究中,我们分析了51例行食管癌或贲门癌手术的患者,以确定手术缓解症状是否可行。我们还分析了围手术期和术后并发症的发病率和死亡率。88%的患者接受了标准的食管切除术,包括经腹-胸入路、胃代食管胸内吻合和黏膜外幽门肌切开术。根据切除术后的组织学检查,53%的手术可能具有治愈性(国际抗癌联盟I期和II期)[1],47%为姑息性手术(国际抗癌联盟III期和IV期)[1]。围手术期30天死亡率为零,围手术期30天发病率为11%(3例患者术后发生肺炎,2例颈部吻合口患者发生吻合口裂开,经保守治疗均完全愈合,而另1例颈部吻合口患者出现喉返神经持续性麻痹。所有患者出院时均完全能够自行进食。43%的患者出现复发性吞咽困难,24%的患者接受了内镜扩张治疗。三年生存率为26%。从这些结果可以得出结论,食管切除术对于大多数不可切除的食管癌患者来说,要么是具有低发病率的良好姑息治疗,要么是在肿瘤早期具有低发病率的潜在治愈性治疗。

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