Bowers C W
Division of Neurosciences, Beckman Research Institute, City of Hope, Duarte, CA 91010.
Trends Neurosci. 1994 Aug;17(8):315-20. doi: 10.1016/0166-2236(94)90168-6.
In recent years, studies have suggested that the complexity of eukaryotic gene regulation, with its recurring and interacting motifs of cis and trans-acting regulatory elements, might result in superfluous gene expression. This conclusion is supported by a variety of experimental results that suggest that non-adaptive gene expression might be common. However, with few exceptions, the practical ramifications of unnecessary gene expression for cell biologists have not been addressed directly; this is particularly true for peptidergic neurophysiology, a field that might be plagued more than most with the consequences of this phenomenon. In this article, Chauncey W. Bowers discusses the superfluous expression of neuropeptides in the nervous system in the context of gene regulation extrapolated from studies in Drosophila.
近年来，研究表明，真核基因调控的复杂性及其顺式和反式作用调控元件的反复出现和相互作用基序，可能导致多余的基因表达。这一结论得到了各种实验结果的支持，这些结果表明非适应性基因表达可能很常见。然而，除了少数例外，细胞生物学家尚未直接探讨不必要基因表达的实际影响；对于肽能神经生理学来说尤其如此，该领域可能比大多数领域更容易受到这一现象后果的困扰。在本文中，昌西·W·鲍尔斯在从果蝇研究推断出的基因调控背景下，讨论了神经系统中神经肽的多余表达。
