Croizat H
Division of Hematology, Albert Einstein College of Medicine, Bronx, New York 10461.
Br J Haematol. 1994 Jul;87(3):592-7. doi: 10.1111/j.1365-2141.1994.tb08318.x.
Plasma levels of GM-CSF, IL-3, IL-6 and IL-1 (alpha,beta) were investigated in steady-state sickle cell patients. We find that SS patients with low levels of HbF (< 9% [LFSS]) are characterized by elevated plasma GM-CSF, whereas in patients with high levels of HbF (HFSS), GM-CSF is not detectable. In contrast, HFSS patients exhibited increased plasma IL-3 (m = 84.8 +/- 57 pg/ml), whereas LFSS patients had lower or no detectable plasma IL-3, IL-1(alpha,beta) and IL-6 were also detected in plasma from some SS patients, but there was no correlation with HbF levels. Normal controls tested negative for all cytokines, except for one individual positive for IL-3. These results are compatible with a model in which the level of haemopoietic stress determines the level of participation of GM-CSF or IL-3 in the regulation of SS circulating BFU-E.
我们对稳态镰状细胞病患者的血浆GM-CSF、IL-3、IL-6和IL-1（α、β）水平进行了研究。我们发现，HbF水平低（<9% [LFSS]）的镰状细胞贫血（SS）患者的特征是血浆GM-CSF升高，而HbF水平高（HFSS）的患者中检测不到GM-CSF。相反，HFSS患者的血浆IL-3升高（m = 84.8 +/- 57 pg/ml），而LFSS患者的血浆IL-3较低或检测不到。一些SS患者的血浆中也检测到了IL-1（α、β）和IL-6，但与HbF水平无关。除一名IL-3呈阳性的个体外，正常对照的所有细胞因子检测均为阴性。这些结果与一种模型相符，即造血应激水平决定了GM-CSF或IL-3参与SS循环BFU-E调节的程度。
