Lessof M H, Sobotka A K, Lichtenstein L M
Johns Hopkins Med J. 1978 Jan;142(1):1-7.
Twelve patients allergic to honeybees were challenged by injections of bee venom; five responded systemically to the venom, with symptoms ranging from angioedema to respiratory distress. These patients were given intramuscular or intravenous infusions of gamma-globulin obtained from the plasma of hyperimmune beekeepers who had high levels of antibody to an allergen (phospholipase A) in the venom. Post-infusion, all five patients tolerated 1.5 to 5 times the venom dose that previously elicited adverse reactions. The quantity of passive IgG antibody infused did not impair the patient's own immune response to venom. These results represent the best available evidence for a direct role for IgG blocking antibodies in clinical protection against anaphylaxis occurring as a result of parenteral antigenic challenge as may be observed in penicillin and insect hypersensitivity.
12名对蜜蜂过敏的患者接受了蜂毒注射激发试验；5名患者出现全身性毒液反应，症状从血管性水肿到呼吸窘迫不等。这些患者接受了从超免疫养蜂人血浆中提取的γ球蛋白的肌肉注射或静脉输注，这些养蜂人对毒液中的一种过敏原（磷脂酶A）具有高水平抗体。输注后，所有5名患者耐受的毒液剂量是之前引发不良反应剂量的1.5至5倍。输注的被动IgG抗体量并未损害患者自身对毒液的免疫反应。这些结果为IgG阻断抗体在临床预防因注射抗原激发而发生的过敏反应中直接发挥作用提供了现有最佳证据，如在青霉素和昆虫过敏中所见。
