Prieto V G, Reed J A, Shea C R
Department of Dermatology, New York Hospital-Cornell Medical Center, NY 10021.
J Cutan Pathol. 1994 Aug;21(4):324-9. doi: 10.1111/j.1600-0560.1994.tb00707.x.
Dermatofibrosarcoma protuberans (DFSP) is a locally aggressive tumor that often recurs after simple excision, and therefore usually requires wide surgical re-excision. It is sometimes difficult to distinguish histologically between residual tumor and scar tissue formed in response to the original biopsy. In an effort to solve this diagnostic problem, we have examined CD34 immunoreactivity in 10 primary biopsies of DFSP, 12 scars, and 7 re-excisional DFSP specimens containing residual tumor adjacent to scar tissue. In all 10 primary biopsies of DFSP, the tumor cells strongly and uniformly expressed CD34. In the 12 scars, only periadnexal cells, endothelial cells, and rare, scattered dendritic cells in the dermis were immunolabeled for CD34. In the 7 re-excisions of DFSP, the foci of residual DFSP were strongly immunolabeled, while the surrounding scar tissue was not. The pattern of CD34 immunoreactivity distinguishes DFSP from scar tissue, and thereby may permit more accurate assessment of surgical margins in re-excisional specimens of DFSP.
隆突性皮肤纤维肉瘤（DFSP）是一种具有局部侵袭性的肿瘤，单纯切除后常复发，因此通常需要广泛手术再次切除。在组织学上，有时难以区分残留肿瘤与因最初活检形成的瘢痕组织。为了解决这一诊断难题，我们检测了10例DFSP原发性活检标本、12例瘢痕以及7例包含与瘢痕组织相邻的残留肿瘤的DFSP再次切除标本中的CD34免疫反应性。在所有10例DFSP原发性活检标本中，肿瘤细胞均强烈且一致地表达CD34。在12例瘢痕中，仅毛囊旁细胞、内皮细胞以及真皮中罕见的散在树突状细胞对CD34呈免疫标记。在7例DFSP再次切除标本中，残留DFSP病灶呈强免疫标记，而周围瘢痕组织则无。CD34免疫反应性模式可将DFSP与瘢痕组织区分开来，从而可能有助于更准确地评估DFSP再次切除标本的手术切缘。
