Laughlin M H
Department of Veterinary Biomedical Sciences, University of Missouri, Columbia 65211.
Med Sci Sports Exerc. 1994 Oct;26(10):1226-9. doi: 10.1249/00005768-199410000-00008.
The purpose of this symposium was to evaluate the hypothesis that the beneficial effects of training are the result of training-induced adaptations in the coronary circulation. The approach is to review, summarize, and evaluate data concerning the effects of exercise training on the coronary circulation. Results indicate that aerobic exercise training induces an increase in both blood flow capacity and capillary exchange capacity. These functional changes are the result of two major types of adaptive responses: structural vascular adaptation and altered control of vascular resistance. Structural vascular adaptation occurs in response to exercise training in at least two forms: increases in the cross-sectional area of the proximal coronary arteries, and angiogenesis. Training-induced changes in coronary vascular control have been shown to include altered responses of the coronary circulation and isolated coronary arteries to vasoactive substances, changes in endothelium-mediated vasoregulation, and alterations in the cellular-molecular control of intracellular free Ca2+ in both endothelial and vascular smooth muscle cells isolated from coronary arteries of exercise trained animals. The potential impact of these training-induced adaptations on the coronary collateral circulation and atherosclerotic coronary disease are discussed.
本次研讨会的目的是评估这样一种假说，即训练的有益效果是训练诱导冠状动脉循环适应性变化的结果。方法是回顾、总结和评估有关运动训练对冠状动脉循环影响的数据。结果表明，有氧运动训练可导致血流能力和毛细血管交换能力均增加。这些功能变化是两种主要适应性反应的结果：血管结构适应性变化和血管阻力控制改变。血管结构适应性变化至少以两种形式发生，以响应运动训练：近端冠状动脉横截面积增加和血管生成。训练诱导的冠状动脉血管控制变化已被证明包括冠状动脉循环和离体冠状动脉对血管活性物质反应的改变、内皮介导的血管调节变化，以及从运动训练动物冠状动脉分离的内皮细胞和血管平滑肌细胞中细胞内游离Ca2+的细胞分子控制改变。讨论了这些训练诱导的适应性变化对冠状动脉侧支循环和动脉粥样硬化性冠状动脉疾病的潜在影响。
